Dynamic Light Scattering (DLS)
Particle Size Analysis | Dynamic Light Scattering
DLS is an optical technique used to determine the size distribution of small particles in suspension by measuring the fluctuations in the intensity of scattered light caused by the Brownian motion of the particles. The rate of these fluctuations is analyzed to calculate the hydrodynamic diameter of the particles, providing insights into their size distribution.
DLS is commonly used in nanotechnology, biotechnology, and pharmaceuticals to study nanoparticle size, protein aggregation, and colloidal stability. It provides a fast, non-invasive method for analyzing particle behavior in liquids, ideal for a range of concentrations and sample types.
DLS Capabilities
| Particle size measurement range | 0.3 nm - 10 µm | |
| Temperature range | 0 °C - 90 °C | |
| pH range | 2 - 12 | |
| Types of measurements | Particle size (hydrodynamic diameter), particle concentration, zeta potential | |
| Common samples | Nanoparticles, powders, liposomes and micelles, proteins and peptides, viruses and virus-like particles, paints and inks, cosmetics, biopolymers, atmospheric aerosols, milk and diary products, adhesives and coatings | |
Particle Size & Stability in Solution
DLS size measurements provide you with a comprehensive understanding of the size characteristics of particles in solution, including:
- Average particle size
- Polydispersity Index: Uniformity of the particle sizes
- Stability Information: Particle size changes with time, pH, and temperature
- Multiangle Particle Sizing (15°, 90°, 175°) – Utilized to improve the accuracy of particle sizing and reliability of measurements
Zeta Potential
Zeta potential measurements using DLS provide you with valuable insights into the surface charge properties of particles in solution, allowing you to:
- Assess stability of colloidal dispersions
- Characterize surface charge of nanoparticles
- Optimize product formulations
- Control flocculation and coagulation processes
Automated Dosing System for Multi-Sample Analysis
Our advanced dosing system allows for precise and controlled addition of solvents or dispersants, with the added capability to adjust pH and sample concentration in real-time. This enables optimal particle dispersion and sample conditioning before analysis, ensuring accurate and consistent results. Automated pH titration and dilution functions also allow for systematic analysis across various pH levels and concentrations, making it ideal for studying pH-dependent particle behavior or concentration-dependent aggregation.
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DLS Applications:
Catalysis
Obtain crucial insights into the size, stability, and dispersibility of catalyst particles, enabling data-driven enhancements for more reliable catalysts.
Critical Micelle Concentration (CMC)
Detect the sudden decrease in particle size as surfactant molecules begin forming micelles at the CMC threshold.
Pharmaceuticals
Analyze the size distribution and stability of liposomes, emulsions, and protein formulations to ensure product efficacy and safety
Polymers
Measuring the size and behavior of polymer particles, is vital for optimizing polymer performance in coatings, adhesives, and more.
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